Over two days (27-28 August 2015), 20 members of TINNET participated in activities and planning for Working Group 5. Thanks for Prof. Birgit Mazurek and Dr. Agnieszka Szczepek for being such welcoming hosts at the Charité University Hospital Berlin, and to Dr Alain Londero for his role as co-chair.... and thanks to all participants for such lively and stimulating debate.